TRP2 (K89) polyclonal antibody 
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Product Name :
TRP2 (K89) polyclonal antibody Background :
The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
TRP2 (K89) polyclonal antibody detects endogenous levels of TRP2 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 50-100 of Human TRP2. Conjugate :
Unconjugated Modification :
Unmodification
TRP2 (K89) polyclonal antibody Background :
The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
TRP2 (K89) polyclonal antibody detects endogenous levels of TRP2 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 50-100 of Human TRP2. Conjugate :
Unconjugated Modification :
Unmodification
Involvement of p38 MAPK signaling pathway in the anti-melanogenic effect of San-bai-tang, a Chinese herbal formula, in B16 cells
PMCID: Pubmed No.:20837127
Inhibition of the p38 and PKA signaling pathways is associated with the anti-melanogenic activity of Qian-wang-hong-bai-san, a Chinese herbal formula, in B16 cells
PMCID: Pubmed No.:21903156
BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells
PMCID: Pubmed No.:24080013
The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2
PMCID: Pubmed No.:26971330
BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells
PMCID: Pubmed No.:24080013
The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2
PMCID: Pubmed No.:26971330
Inhibition of melanogenesis by jineol from Scolopendra subspinipes mutilans via MAP-Kinase mediated MITF downregulation and the proteasomal degradation of tyrosinase
PMCID: Pubmed No.:28393917
The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2
PMCID: Pubmed No.:26971330
Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma
PMCID: Pubmed No.:27683122
Photoreceptor degeneration in microphthalmia (Mitf) mice: partial rescue by pigment epithelium-derived factor
PMCID: Pubmed No.:30651300
Attenuation of melanogenesis by Nymphaea nouchali (Burm. f) flower extract through the regulation of cAMP/CREB/MAPKs/MITF and proteasomal degradation of tyrosinase
PMCID: Pubmed No.:30224716
Fuzhuan Brick Tea Boosts Melanogenesis and Prevents Hair Graying through Reduction of Oxidative Stress via NRF2-HO-1 Signaling
PMCID: Pubmed No.:35326249
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.