S100 α (A18) polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
S100 α (A18) polyclonal antibody Background :
The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca 2+-binding protein), S-100 α and β, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin α and parvalbumin β (also designated oncomodulin). The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. Research also indicates that the S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100α chain and S-100β chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of either two α chains, two β chains or one α and one β chain. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
S100 α (A18) polyclonal antibody detects endogenous levels of S100 A1 protein. Immunogen :
Synthetic peptide, corresponding to the N-terminal of Human S100 α. Conjugate :
Unconjugated Modification :
Unmodification
S100 α (A18) polyclonal antibody Background :
The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca 2+-binding protein), S-100 α and β, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin α and parvalbumin β (also designated oncomodulin). The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. Research also indicates that the S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100α chain and S-100β chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of either two α chains, two β chains or one α and one β chain. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
S100 α (A18) polyclonal antibody detects endogenous levels of S100 A1 protein. Immunogen :
Synthetic peptide, corresponding to the N-terminal of Human S100 α. Conjugate :
Unconjugated Modification :
Unmodification
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Immunohistochemistry (IHC) analyzes of S100 α (A18) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.
Immunohistochemical detection of S100A1 in the postmortem diagnosis of acute myocardial infarction.
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Involvement of MAPK ERK Activation in Upregulation of Water Channel Protein Aquaporin 1 in a Mouse Model of Bell's Palsy
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Involvement of MAPK ERK Activation in Upregulation of Water Channel Protein Aquaporin 1 in a Mouse Model of Bell’s Palsy
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Involvement of MAPK ERK Activation in Upregulation of Water Channel Protein Aquaporin 1 in a Mouse Model of Bell's Palsy
PMCID: Pubmed No.:25527444
A synthetic oxygen carrier-olfactory ensheathing cell composition system for the promotion of sciatic nerve regeneration
PMCID: Pubmed No.:24246645
Involvement of MAPK ERK Activation in Upregulation of Water Channel Protein Aquaporin 1 in a Mouse Model of Bell’s Palsy
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Involvement of MAPK ERK Activation in Upregulation of Water Channel Protein Aquaporin 1 in a Mouse Model of Bell’s Palsy
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iASPP overexpression is associated with clinical outcome in spinal chordoma and influences cellular proliferation, invasion, and sensitivity to cisplatin in vitro
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Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.