Product Name :
DMGDH polyclonal antibody Background :
DMGDH (dimethylglycine dehydrogenase), also known as ME2GLYDH or DMGDHD, is an 866 amino acid mitochondrial protein that plays a role in choline catabolism by catalyzing the demethylation of dimethylglycine to form sarcosine. Existing as a monomer that belongs to the gcvT family, DMGDH utilizes flavin adenine dinucleotide (FAD) and folate as cofactors. DMGDH is encoded by a gene that maps to human chromosome 5q14.1, defects of which are the cause of DMGDH deficiency (DMGDHD). Patients with DMGDHD experience muscle fatigue, have a fish-like odor and excrete an elevated level of N,N-dimethylglycine (DMG) in urine. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
DMGDH polyclonal antibody detects endogenous levels of DMGDH protein. Immunogen :
Synthetic peptide, corresponding to amino acids 810-860 of Human DMGDH. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of DMGDH polyclonal antibody at 1:500 dilution Lane1:CT26 whole cell lysate(40ug) Lane2:H9C2 whole cell lysate(40ug) Lane3:L02 whole cell lysate(40ug) Lane4:MCF-7 whole cell lysate(40ug)

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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