Product Name :
CMTM3 polyclonal antibody Background :
Chemokines are members of a superfamily of small inducible, secreted, proinflammatory cytokines. Members of the chemokine-like factor superfamily (CKLFSF) share similarities with both chemokine and transmembrane 4 superfamilies of signaling molecules. As a member of the CKLFSF family of proteins, CMTM3 (CKLF-like MARVEL transmembrane domain-containing protein 3), also known as Chemokine-like factor superfamily member 3, is a 182 amino acid membrane protein that is expressed in placenta, testis and leukocytes. The gene encoding CMTM3 resides in a tight gene cluster on human chromosome 16 with CKLF, CMTM1, CMTM2 and CMTM4. Silencing or downregulation of CMTM3 due to aberrant promoter CpG methylation of its gene is frequently observed in common carcinomas, suggesting that CMTM3 is a tumor supressor. CMTM3 also seems to repress activation of AR (androgen receptor) and may therefore play a role in the maturation and maintenance of male reproduction. There are two isoforms of CMTM3 that are produced as a result of alternative splicing events. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
CMTM3 polyclonal antibody detects endogenous levels of CMTM3 protein. Immunogen :
Synthetic peptide, corresponding Human CMTM3. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of CMTM3 polyclonal antibody at 1:500 dilution Lane1:The Testis tissue lysate of Rat(40ug) Lane2:CT26 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:COS-7 whole cell lysate(40ug)

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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