STEAP2 polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
STEAP2 polyclonal antibody Background :
STEAP2 (six transmembrane epithelial antigen of the prostate 2), also known as STMP, IPCA1, PUMPCn, STAMP1 or PCANAP1, is a 490 amino acid multi-pass membrane protein that localizes to the cell membrane and the endosomal membrane, as well as to the Golgi and to vesicular tubular structures in the cytosol. Highly expressed in prostate and present at lower levels in kidney, heart, ovary, brain and pancreas, STEAP2 contains one ferric oxidoreductase domain and, using FAD as a cofactor, functions as a metalloreductase that is able to reduce both Cu(2+) and Fe(3+) to Cu(1+) and Fe(2+), respectively, thereby playing a role in iron and copper metabolism. Overexpression of STEAP2 is associated with the progression of prostate cancer, suggesting a role for STEAP2 in tumorigenesis. Multiple isoforms of STEAP2 exist due to alternative splicing events. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
STEAP2 polyclonal antibody detects endogenous levels of STEAP2 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 440-485 of Human STEAP2. Conjugate :
Unconjugated Modification :
Unmodification
STEAP2 polyclonal antibody Background :
STEAP2 (six transmembrane epithelial antigen of the prostate 2), also known as STMP, IPCA1, PUMPCn, STAMP1 or PCANAP1, is a 490 amino acid multi-pass membrane protein that localizes to the cell membrane and the endosomal membrane, as well as to the Golgi and to vesicular tubular structures in the cytosol. Highly expressed in prostate and present at lower levels in kidney, heart, ovary, brain and pancreas, STEAP2 contains one ferric oxidoreductase domain and, using FAD as a cofactor, functions as a metalloreductase that is able to reduce both Cu(2+) and Fe(3+) to Cu(1+) and Fe(2+), respectively, thereby playing a role in iron and copper metabolism. Overexpression of STEAP2 is associated with the progression of prostate cancer, suggesting a role for STEAP2 in tumorigenesis. Multiple isoforms of STEAP2 exist due to alternative splicing events. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
STEAP2 polyclonal antibody detects endogenous levels of STEAP2 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 440-485 of Human STEAP2. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of STEAP2 polyclonal antibody at 1:500 dilution Lane1:HEH293T whole cell lysate(40ug) Lane2:The Spleen tissue lysate of Rat(30ug) Lane3:The Spleen tissue lysate of Mouse(30ug)
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.