IL13RA2 polyclonal antibody 
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Product Name :
IL13RA2 polyclonal antibody Background :
The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Rα1 and 2. IL-13Rα1 exists as a heterodimer of IL-13Rα1 and IL-4Rα as a signaling subunit, whereas IL-13Rα2 acts as a decoy receptor for IL-13. Furthermore, TNFα or IL-4 stimulation induces IL-13Rα2 upregulation, while IL-13Rα1 is constitutively expressed. Cell surface localization of IL-13Rα2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Rα1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Rα2 expression is highest in glioma cells. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
IL13RA2 polyclonal antibodydetects endogenous levels of IL13RA2 protein. Immunogen :
A synthetic peptide corresponding to residues 251-296 in Human IL13RA2. Conjugate :
Unconjugated Modification :
Unmodification
IL13RA2 polyclonal antibody Background :
The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Rα1 and 2. IL-13Rα1 exists as a heterodimer of IL-13Rα1 and IL-4Rα as a signaling subunit, whereas IL-13Rα2 acts as a decoy receptor for IL-13. Furthermore, TNFα or IL-4 stimulation induces IL-13Rα2 upregulation, while IL-13Rα1 is constitutively expressed. Cell surface localization of IL-13Rα2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Rα1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Rα2 expression is highest in glioma cells. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
IL13RA2 polyclonal antibodydetects endogenous levels of IL13RA2 protein. Immunogen :
A synthetic peptide corresponding to residues 251-296 in Human IL13RA2. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of IL13RA2 polyclonal antibodyat 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:The liver tissue lysate of Mouse(30ug) Lane3:The liver tissue lysate of Rat(30ug)
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.