SH2D4A polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
SH2D4A polyclonal antibody Background :
SH2D4A (SH2 domain containing protein 4A), also known as SH2A, is a ubiquitously expressed 454 amino acid docking protein that belongs to the SH2 signaling protein family. Members of this family typically participate in intracellular signaling. Localizing to the cytoplasm, SH2D4A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. This suggests that SH2D4A, via its SH2 domain, may play an important function in cellular signal transduction. More specifically, SH2D4A is believed to function as an inhibiting factor in PKC signal transduction. In addition, SH2D4A exhibits abnormal expression in various cancers, implying that it may be involved in tumorigenesis. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
SH2D4A polyclonal antibody detects endogenous levels of SH2D4A protein. Immunogen :
A synthetic peptide corresponding to residues in Human SH2D4A. Conjugate :
Unconjugated Modification :
Unmodification
SH2D4A polyclonal antibody Background :
SH2D4A (SH2 domain containing protein 4A), also known as SH2A, is a ubiquitously expressed 454 amino acid docking protein that belongs to the SH2 signaling protein family. Members of this family typically participate in intracellular signaling. Localizing to the cytoplasm, SH2D4A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. This suggests that SH2D4A, via its SH2 domain, may play an important function in cellular signal transduction. More specifically, SH2D4A is believed to function as an inhibiting factor in PKC signal transduction. In addition, SH2D4A exhibits abnormal expression in various cancers, implying that it may be involved in tumorigenesis. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
SH2D4A polyclonal antibody detects endogenous levels of SH2D4A protein. Immunogen :
A synthetic peptide corresponding to residues in Human SH2D4A. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of SH2D4A polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.