Product Name :
CCR4 polyclonal antibody Background :
C-C or β chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potentchemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include CKR-1,CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7 and the Duffy blood group antigen. Each of these receptors are G protein-coupled,seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation. However, this receptor family has also been shown to facilitate viral infection. CKR-4 (C-C chemokine receptor type 4), also known as CCR4 or CMKBR4, is a 360 amino acidmulti-pass membrane protein that localizes to the cell membrane and belongs to the C-C chemokine receptor family. Expressed at high levels in peripheral blood leukocytes and thymustissue, CKR-4 functions as a high affinity receptor for C-C type chemokines and is thought to be involved in hippocampal-neuron survival. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
CCR4 polyclonal antibody detects endogenous levels of CCR4 protein. Immunogen :
A synthetic peptide corresponding to residues in Human CCR4. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of CCR4 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:NIH-3T3 whole cell lysate

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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