HOXC8 polyclonal antibody 
Datasheet
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Product Name :
HOXC8 polyclonal antibody Background :
HoxC8 (Homeobox protein Hox-C8, Hox-3A) is a 242 amino acid protein encoded by the human gene HOXC8. HoxC8 belongs to the Antp homeobox family and contains one homeobox DNA-binding domain. The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. Homeobox region 3 contains at least seven homeoboxes within 160 kb of DNA. Overexpression of the HOXC8 transgene causes cartilage defects, the severity of which depends upon transgene dosage. This abnormal cartilage is characterized by an accumulation of proliferating chondrocytes and reduced maturation. Since HoxC8 is normally expressed in chondrocytes, it may be responsible for skeletal development other than pattern formation in a tissue-specific manner, hypothetically by controlling the progression of cells along the chondrocyte differentiation pathway. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
HOXC8 polyclonal antibody detects endogenous levels of HOXC8 protein. Immunogen :
A synthetic peptide corresponding to residues in Human HOXC8 Conjugate :
Unconjugated Modification :
Unmodification
HOXC8 polyclonal antibody Background :
HoxC8 (Homeobox protein Hox-C8, Hox-3A) is a 242 amino acid protein encoded by the human gene HOXC8. HoxC8 belongs to the Antp homeobox family and contains one homeobox DNA-binding domain. The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. Homeobox region 3 contains at least seven homeoboxes within 160 kb of DNA. Overexpression of the HOXC8 transgene causes cartilage defects, the severity of which depends upon transgene dosage. This abnormal cartilage is characterized by an accumulation of proliferating chondrocytes and reduced maturation. Since HoxC8 is normally expressed in chondrocytes, it may be responsible for skeletal development other than pattern formation in a tissue-specific manner, hypothetically by controlling the progression of cells along the chondrocyte differentiation pathway. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
HOXC8 polyclonal antibody detects endogenous levels of HOXC8 protein. Immunogen :
A synthetic peptide corresponding to residues in Human HOXC8 Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of HOXC8 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.