Product Name :
Na+ CP type IXα polyclonal antibody Background :
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type IXα, also known as SCN9A (sodium channel protein type 9 subunit α), NENA, PN1, Nav1.7 or ETHA, is a 1,988 amino acid multi-pass membrane protein that belongs to the voltage-gated sodium channel family. Expressed in dorsal root ganglion, smooth muscle cells and in the central and peripheral nervous system, Na+ CP type IXα functions to mediate the voltage-dependent sodium ion permeability of membranes, specifically forming a sodium-selective ion channel through which sodium may pass. Via its ability to control the flow of sodium in and out of excitable membranes, Na+ CP type IXα plays an important role in the inflammatory pain response. Defects in the gene encoding Na+ CP type IXα are the cause of primary erythermalgia, autosomal recessive congenital indifference to pain and paroxysmal extreme pain disorder (PEPD), all of which are genetic pain disorders. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Na+ CP type IXα polyclonal antibody detects endogenous levels of Na+ CP type IXα protein. Immunogen :
Synthetic peptide, corresponding to amino acids 702-747 of Human Na+ CP type IXα. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of Na+ CP type IXα polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:NIH-3T3 cell lysate Lane3:H9C2 cell lysate

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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