Product Name :
KV10.1 polyclonal antibody Background :
Voltage-gated potassium channels play an essential role in controlling cellular excitability in the nervous system. They regulate a variety of properties including membrane potential as well as the frequency and structure of action potentials. KCNH1 (potassium voltage-gated channel, subfamily H (eag-related), member 1), also known as ether-a-go-go potassium channel 1, voltage-gated potassium channel subunit Kv10.1, EAG, EAG1 or h-eag, is a 989 amino acid multi-pass membrane protein belonging to the potassium channel family and H (Eag) subfamily. KCNH1 is highly expressed in myoblasts and brain, forms two alternatively spliced isoforms and exists as a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. Encoded by a gene located on human chromosome 1, KCNH1 forms a heteromultimer with KCNH5 and also interacts with ALG10. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
KV10.1 polyclonal antibody detects endogenous levels of KV10.1 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 762-807 of Human KV10.1. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of KV10.1 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:NIH-3T3 cell lysate Lane3:H9C2 cell lysate

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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