c-Myc is Required for BRAFV600E-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis PMCID:    Pubmed No.:28656062 Lipoxin A 4 Inhibits Transition of Epithelial to Mesenchymal Cells in Proximal Tubules PMCID:    Pubmed No.:20714129 Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kB activation PMCID:    Pubmed No.:21078355 Inhibition of vascular endothelial growth factor-induced angiogenesis by scopoletin through interrupting the autophosphorylation of VEGF receptor 2 and its downstream signaling pathways PMCID:    Pubmed No.:21078410 Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium PMCID:    Pubmed No.:21081149 Modified Si-Miao-San Extract inhibits inflammatory response and modulates insulin sensitivity in hepatocytes through an IKKβ/IRS-1/Akt-dependent pathway PMCID:    Pubmed No.:21296137 PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells PMCID:    Pubmed No.:21328610 Effect of CIPC and intervention of Ca2+-regulated factors on CaN, cbl-b and p-AKT expression in neurons PMCID:    Pubmed No.:21382357 HOXB7 as a prognostic factor and mediator of colorectal cancer progression PMCID:    Pubmed No.:21474578 Isomalto oligosaccharide sulfate inhibits tumor growth and metastasis of hepatocellular carcinoma in nude mice PMCID:    Pubmed No.:21513518 Small interfering RNA targeting integrin-linked kinase inhibited the growth and induced apoptosis in human bladder cancer cells PMCID:    Pubmed No.:21601006 Monoclonal antibody to six transmembrane epithelial antigen of prostate-4 influences insulin sensitivity by attenuating phosphorylation of P13K (P85) and Akt: Possible mitochondrial mechanism PMCID:    Pubmed No.:21647634 Prevention of FGF-2-induced angiogenesis by scopoletin, a coumarin compound isolated from Erycibe obtusifolia Benth, and its mechanism of action PMCID:    Pubmed No.:21896339 MiR-223 Suppresses Cell Proliferation by Targeting IGF-1R PMCID:    Pubmed No.:22073238 Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity PMCID:    Pubmed No.:22122827 Does insulin bolster antioxidant defenses via the ERK-Akt-Nrf2 pathway ? PMCID:    Pubmed No.:22149292 Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer PMCID:    Pubmed No.:22292935 Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner PMCID:    Pubmed No.:22314193 Disruption of mindin exacerbates cardiac hypertrophy and fibrosis PMCID:    Pubmed No.:22367478 Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress PMCID:    Pubmed No.:22522094 Downregulation of integrin-linked kinase inhibits epithelial-to-mesenchymal transition and metastasis in bladder cancer cells PMCID:    Pubmed No.:22570869 Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer PMCID:    Pubmed No.:22717106 XJP-1 protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by inhibiting NADPH oxidase subunit expression and modulating the PI3K/Akt/eNOS pathway PMCID:    Pubmed No.:22980246 Gleditsioside B, a triterpene saponin isolated from the anomalous fruits of Gleditsia sinensis Lam., abrogates bFGF-induced endothelial cell migration through preventing the activation of MMP-2 and FAK via inhibiting ERK and PI3K/AKT signaling pathways PMCID:    Pubmed No.:23026290 Combined Treatment with an Oncolytic Adenovirus and Antitumor Activity of Vincristine against Retinoblastoma Cells PMCID:    Pubmed No.:23109819 Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells PMCID:    Pubmed No.:23255485 The expression of chitinase 3-like 1: a novel prognostic predictor for hepatocellular carcinoma PMCID:    Pubmed No.:23525579 Mechanisms underlying protective effects of trimetazidine on endothelial progenitor cells biological functions against H2O2-induced injury: Involvement of antioxidation and Akt/eNOS signaling pathways PMCID:    Pubmed No.:23528356 5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins PMCID:    Pubmed No.:23533482 Effect of 5-hydroxymethylfurfural derived from processed Cornus officinalis on the prevention of high glucose-induced oxidative stress in human umbilical vein endothelial cells and its mechanism PMCID:    Pubmed No.:23578643 miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. PMCID:    Pubmed No.:23624080 Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis PMCID:    Pubmed No.:23684542 A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells PMCID:    Pubmed No.:23703635 β-Catenin overexpression is associated with gefitinib resistance in non-small cell lung cancer cells PMCID:    Pubmed No.:23707949 Small interfering RNA targeting ILK inhibits metastasis in human tongue cancer cells through repression of epithelial-to-mesenchymal transition PMCID:    Pubmed No.:23707970 Activation of cannabinoid type 2 receptor by JWH133 protects heart against ischemia/reperfusion-induced apoptosis. PMCID:    Pubmed No.:23711495 The anti-apoptotic and neuro-protective effects of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) on acute optic nerve injury is transient. PMCID:    Pubmed No.:23933426 Cucurmosin induces the apoptosis of human pancreatic cancer CFPAC-1 cells by inactivating the PDGFR-b signalling pathway PMCID:    Pubmed No.:23950591 Grape Seed Procyanidin Reversal of P-glycoprotein Associated Multi-Drug Resistance via Down-regulation of NF-κB and MAPK/ERK Mediated YB-1 Activity in A2780/T Cells PMCID:    Pubmed No.:23967153 Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway. PMCID:    Pubmed No.:24098937 MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2 PMCID:    Pubmed No.:24293274 Upregulation of estrogen receptor mediates migration, invasion and proliferation of endometrial carcinoma cells by regulating the PI3K/AKT/mTOR pathway PMCID:    Pubmed No.:24366110 The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK-and MAPK-dependent mechanisms PMCID:    Pubmed No.:24490809 Ribonuclease inhibitor up-regulation inhibits the growth and induces apoptosis in murine melanoma cells through repression of angiogenin and ILK/PI3K/AKT signaling pathway. PMCID:    Pubmed No.:24769129 High uric acid directly inhibits insulin signalling and induces insulin resistance PMCID:    Pubmed No.:24769205 Tripterygium Glycosides Impairs the Proliferation of Granulosa Cells and Decreases the Reproductive Outcomes in Female Rats. PMCID:    Pubmed No.:24831781 GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17β-estradiol in triple-negative breast cancer cells PMCID:    Pubmed No.:24874276 Effect of Tenuifoliside A isolated from Polygala tenuifolia on the ERK and PI3K pathways in C6 glioma cells. PMCID:    Pubmed No.:24877714 MiR-205 inhibits cell apoptosis by targeting phosphatase and tensin homolog deleted on chromosome ten in endometrial cancer ishikawa cells PMCID:    Pubmed No.:24929707 Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-κB/p65, Akt and MAPK pathway in THP-1 cells PMCID:    Pubmed No.:24905527 The Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Protects against Dyslipidemia-Related Kidney Injury in Apolipoprotein E Knockout Mice. PMCID:    Pubmed No.:24972137 A novel Pseudolaric acid B derivative, Hexahydropseudolaric acid B, exterts immunomodulatory effect in vitro/in vivo evaluation PMCID:    Pubmed No.:25446920 Angiogenin interacts with ribonuclease inhibitor regulating PI3K/AKT/mTOR signaling pathway in bladder cancer cells PMCID:    Pubmed No.:25193113 Ubiquitin‑specific protease 22‑induced autophagy is correlated with poor prognosis of pancreatic cancer PMCID:    Pubmed No.:25241857 Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells PMCID:    Pubmed No.:25857968 Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients PMCID:    Pubmed No.:25590580 Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells PMCID:    Pubmed No.:25694047 PM2. 5‐induced oxidative stress increases adhesion molecules expression in human endothelial cells through the ERK/AKT/NF‐κB‐dependent pathway PMCID:    Pubmed No.:25876056 Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma PMCID:    Pubmed No.:26047481 Decreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1α/Stra13 pathway. PMCID:    Pubmed No.:25801056 Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway PMCID:    Pubmed No.:26318432 Ethanolic Ginkgo biloba leaf extract prevents renal fibrosis through Akt/mTOR signaling in diabetic nephropathy PMCID:    Pubmed No.:26547529 Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitro and in vivo evidences PMCID:    Pubmed No.:26374551 Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway PMCID:    Pubmed No.:26404526 Effects of lentivirus-mediated shRNA targeting integrin-linked kinase on oral squamous cell carcinoma in vitro and in vivo PMCID:    Pubmed No.:26531674 Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy PMCID:    Pubmed No.:26607438 Activation of GPER suppresses epithelial mesenchymal transition of triple negative breast cancer cells via NF-κB signals PMCID:    Pubmed No.:26160845 The effects of tao-Hong-si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease PMCID:    Pubmed No.:26802785 High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo PMCID:    Pubmed No.:26836389 Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition PMCID:    Pubmed No.:26921757 miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma PMCID:    Pubmed No.:27010857 The Study of Traditional Chinese Medical Elongated-needle Therapy promoting Neurological recovery mechanism after Spinal Cord Injury in Rats PMCID:    Pubmed No.:27085942 miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/ AKT pathway in nasopharyngeal carcinoma PMCID:    Pubmed No.:27010857 A novel Pseudolaric acid B derivative, Hexahydropseudolaric acid B, exterts immunomodulatory effect in vitro/in vivo evaluation PMCID:    Pubmed No.:25446920 Angiogenin interacts with ribonuclease inhibitor regulating PI3K/AKT/mTOR signaling pathway in bladder cancer cells PMCID:    Pubmed No.:25193113 Ubiquitin‑specific protease 22‑induced autophagy is correlated with poor prognosis of pancreatic cancer PMCID:    Pubmed No.:25241857 Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway. PMCID:    Pubmed No.:24098937 Ethanolic Ginkgo biloba leaf extract prevents renal fibrosis through Akt/mTOR signaling in diabetic nephropathy PMCID:    Pubmed No.:26547529 Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitro and in vivo evidences PMCID:    Pubmed No.:26374551 Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway PMCID:    Pubmed No.:26404526 Effects of lentivirus-mediated shRNA targeting integrin-linked kinase on oral squamous cell carcinoma in vitro and in vivo PMCID:    Pubmed No.:26531674 Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy PMCID:    Pubmed No.:26607438 Activation of GPER suppresses epithelial mesenchymal transition of triple negative breast cancer cells via NF-κB signals PMCID:    Pubmed No.:26160845 The effects of tao-Hong-si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease PMCID:    Pubmed No.:26802785 High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo PMCID:    Pubmed No.:26836389 Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition PMCID:    Pubmed No.:26921757 miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma PMCID:    Pubmed No.:27010857 The Study of Traditional Chinese Medical Elongated-needle Therapy promoting Neurological recovery mechanism after Spinal Cord Injury in Rats PMCID:    Pubmed No.:27085942 Ribonuclease inhibitor up-regulation inhibits the growth and induces apoptosis in murine melanoma cells through repression of angiogenin and ILK/PI3K/AKT signaling pathway. PMCID:    Pubmed No.:24769129 High uric acid directly inhibits insulin signalling and induces insulin resistance PMCID:    Pubmed No.:24769205 Tripterygium Glycosides Impairs the Proliferation of Granulosa Cells and Decreases the Reproductive Outcomes in Female Rats. PMCID:    Pubmed No.:24831781 MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2 PMCID:    Pubmed No.:24293274 Upregulation of estrogen receptor mediates migration, invasion and proliferation of endometrial carcinoma cells by regulating the PI3K/AKT/mTOR pathway PMCID:    Pubmed No.:24366110 The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK-and MAPK-dependent mechanisms PMCID:    Pubmed No.:24490809 Antitumor and anti-metastatic mechanisms of Rhizoma paridis saponins in Lewis mice PMCID:    Pubmed No.:29148169 Paeoniflorin suppresses lipid accumulation and alleviates insulin resistance by regulating the Rho kinase/IRS-1 pathway in palmitate-induced HepG2Cells PMCID:    Pubmed No.:28380411 The combination effects of Shen-Ling-Bai-Zhu on promoting apoptosis of transplanted H22 hepatocellular carcinoma in mice receiving chemotherapy PMCID:    Pubmed No.:27235019 The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease PMCID:    Pubmed No.:26802785 High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinoma PMCID:    Pubmed No.:26463718 Estrogen-related receptor (ERR) γ protects against puromycin aminonucleoside-induced podocyte apoptosis by targeting PI3K/Akt signaling PMCID:    Pubmed No.:27417234 Pretreatment with low dose etomidate prevents etomidate-induced rat adrenal insufficiency by regulating oxidative stress-related MAPKs and apoptosis PMCID:    Pubmed No.:25989534 Downregulation of prostaglandin E2 is involved in hindgut mucosal damage in lactating goats fed a high‐concentrate diet PMCID:    Pubmed No.:26593381 Downregulation of Foxc2 enhances apoptosis induced by 5-fluorouracil through activation of MAPK and AKT pathways in colorectal cancer PMCID:    Pubmed No.:26893778 Wushenziye Formula Improves Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus via PTP1B-IRS1-Akt-GLUT4 Signaling Pathway PMCID:    Pubmed No.:29479370 Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma PMCID:    Pubmed No.:27542262 Cytological study on the regulation of lymphocyte homing in the chicken spleen during LPS stimulation PMCID:    Pubmed No.:28061467 PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis PMCID:    Pubmed No.:25826083 High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma PMCID:    Pubmed No.:28938613 miR-382 targeting PTEN-Akt axis promotes liver regeneration PMCID:    Pubmed No.:26636539 USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma PMCID:    Pubmed No.:29981430 GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway PMCID:    Pubmed No.:33591943 Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells PMCID:    Pubmed No.:29608021 Auranofin Enhances Ibrutinib's Anticancer Activity in EGFR-Mutant Lung Adenocarcinoma PMCID:    Pubmed No.:30065099 ERα and/or ERβ activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice PMCID:    Pubmed No.:30201537 Neuroprotective effects of novel compound Tozan on cognition, neurogenesis and apoptosis in diabetes PMCID:    Pubmed No.:34734023 Activation of ERα and/or ERβ ameliorates cognitive impairment and apoptosis in streptozotocin-induced diabetic mice PMCID:    Pubmed No.:30096284 Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo PMCID:    Pubmed No.:31259992 The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway PMCID:    Pubmed No.:31737114 PTPN1 promotes the progression of glioma by activating the MAPK/ERK and PI3K/AKT pathways and is associated with poor patient survival PMCID:    Pubmed No.:31173266 Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer PMCID:    Pubmed No.:32851058 Effects of PHA-665752 and vemurafenib combination treatment on in vitro and murine xenograft growth of human colorectal cancer cells with BRAFV600E mutations PMCID:    Pubmed No.:29456739 Follicle loss and PTEN/PI3K/mTOR signaling pathway activated in LepR-mutated mice PMCID:    Pubmed No.:30145913 Mechanism of Shiliu Buxue Syrup for anemia using integrated metabolomics and network pharmacology PMCID:    Pubmed No.:35690102 LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing PMCID:    Pubmed No.:36650118 Neuroprotective effects of novel compound FMDB on cognition, neurogenesis and apoptosis in APP/PS1 transgenic mouse model of Alzheimer's disease PMCID:    Pubmed No.:36893915 Identification of a diketopiperazine-based O-GlcNAc transferase inhibitor sensitizing hepatocellular carcinoma to CDK9 inhibition PMCID:    Pubmed No.:37247228