Lamin A/C (S17) polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
Lamin A/C (S17) polyclonal antibody Background :
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed CED-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Lamin A/C (S17) polyclonal antibody detects endogenous levels of Lamin A/C protein. Immunogen :
Synthetic peptide, corresponding to the N-terminus of Human Lamin A. Conjugate :
Unconjugated Modification :
Unmodification
Lamin A/C (S17) polyclonal antibody Background :
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed CED-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Lamin A/C (S17) polyclonal antibody detects endogenous levels of Lamin A/C protein. Immunogen :
Synthetic peptide, corresponding to the N-terminus of Human Lamin A. Conjugate :
Unconjugated Modification :
Unmodification
-
Western blot (WB) analysis of Lamin A/C(S17) polyclonal antibody at 1:2000 dilution Lane1:HepG2 whole cell lysate(25ug) Lane2:PC12 whole cell lysate(30ug) Lane3:RAW264.7 whole cell lysate(30ug) -
Immunohistochemistry (IHC) analyzes of Lamin A/C (S17) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Bcl-3, induced by Tax and HTLV-1, inhibits NF-κB activation and promotes autophagy
PMCID: Pubmed No.:24044922
Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway.
PMCID: Pubmed No.:24534483
Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells.
PMCID: Pubmed No.:24666416
Melatonin promotes the acquisition of neural identity through ERK1/2 activation
PMCID: Pubmed No.:24942200
LW‐213 induces G2/M cell cycle arrest through AKT/GSK3β/β‐catenin signaling pathway in human breast cancer cells
PMCID: Pubmed No.:25945460
The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-cells from ER-Stress-Mediated Apoptosis.
PMCID: Pubmed No.:26157144
Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation
PMCID: Pubmed No.:26947454
Inflammasome-independent NLRP3 is required for epithelial-mesenchymal transition in colon cancer cells
PMCID: Pubmed No.:26968633
Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation
PMCID: Pubmed No.:26947454
Inflammasome-independent NLRP3 is required for epithelial-mesenchymal transition in colon cancer cells
PMCID: Pubmed No.:26968633
Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway.
PMCID: Pubmed No.:24534483
Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells.
PMCID: Pubmed No.:24666416
Supplementing the maternal diet of rats with butyrate enhances mitochondrial biogenesis in the skeletal muscles of weaned offspring
PMCID: Pubmed No.:28091351
LW‐213 induces G2/M cell cycle arrest through AKT/GSK3β/β‐catenin signaling pathway in human breast cancer cells
PMCID: Pubmed No.:25945460
Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxyisoflavone derivatives
PMCID: Pubmed No.:27473965
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.