ICAM-1 (Q506) polyclonal antibody 
Datasheet
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MSDS
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Product Name :
ICAM-1 (Q506) polyclonal antibody Background :
ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase in inflammation. Also, ICAM1 is detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
ICAM-1 (Q506) polyclonal antibody detects endogenous levels of ICAM-1 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 471-520 of Human ICAM-1. Conjugate :
Unconjugated Modification :
Unmodification
ICAM-1 (Q506) polyclonal antibody Background :
ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase in inflammation. Also, ICAM1 is detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
ICAM-1 (Q506) polyclonal antibody detects endogenous levels of ICAM-1 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 471-520 of Human ICAM-1. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of ICAM-1 (Q506) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(20ug) Lane2:A549 whole cell lysate(40ug) Lane3:H1792 whole cell lysate(40ug) Lane4:C6 whole cell lysate(40ug) Lane5:SP2/0 whole cell lysate(40ug)
Lipoxin A4 attenuation of endothelial inflammation response mimicking pancreatitis-induced lung injury.
PMCID: Pubmed No.:24000382
Urocortin increased endothelial ICAM1 by cPLA2-dependent NF-κB and PKA pathways in HUVECs
PMCID: Pubmed No.:24363440
TLR4 is involved in the pathogenic effects observed in a murine model of antiphospholipid syndrome
PMCID: Pubmed No.:26065621
Aging increases the susceptibility of cisplatin-induced nephrotoxicity
PMCID: Pubmed No.:26534724
The protective effect of melatonin on smoke‐induced vascular injury in rats and humans: a randomized controlled trial (RCT)
PMCID: Pubmed No.:26681403
The Effects of NF-κB and c-Jun/AP-1 on the Expression of Prothrombotic and Proinflammatory Molecules Induced by Anti-β2GPI in Mouse
PMCID: Pubmed No.:26829121
Aging increases the susceptibility of cisplatin-induced nephrotoxicity
PMCID: Pubmed No.:26534724
The protective effect of melatonin on smoke‐induced vascular injury in rats and humans: a randomized controlled trial (RCT)
PMCID: Pubmed No.:26681403
The Effects of NF-κB and c-Jun/AP-1 on the Expression of Prothrombotic and Proinflammatory Molecules Induced by Anti-β2GPI in Mouse
PMCID: Pubmed No.:26829121
Urocortin increased endothelial ICAM1 by cPLA2-dependent NF-κB and PKA pathways in HUVECs
PMCID: Pubmed No.:24363440
DIFFERENTIATED EMBRYONIC CHONDROCYTE EXPRESSED GENE-1 IS A CENTRAL SIGNALING COMPONENT IN THE DEVELOPMENT OF COLLAGEN-INDUCED RHEUMATOID ARTHRITIS
PMCID: Pubmed No.:36739947
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.