Product Name :
ADNP polyclonal antibody Background :
Activity-dependent neuroprotector (ADNP), also designated activity-dependent neuroprotective protein, is a nuclear protein that functions as a putative transcription factor and may participate in normal growth and cancer proliferation. ADNP is a highly conserved vasoactive intestinal peptide (VIP) responsive gene that is expressed profusely in the brain (primarily cerebellum and cortex regions) and is crucial for brain formation and embryonic development. ADNP is also highly expressed in kidney, placenta, heart, skeletal muscle, breast, and colon cancer tissues. Studies indicate that neuroprotection by subpicomolar PACAP38 might be mediated partially by expression of ADNP. A correlation between brain injuries and elevated ADNP levels indicates a potential involvement of ADNP in an endogenous compensatory mechanism. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
ADNP polyclonal antibody detects endogenous levels of ADNP protein. Immunogen :
Synthetic peptide, corresponding Human ADNP. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of ADNP polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:The Kidney tissue lysate of Rat(40ug) Lane4:The Embryo tissue lysate of Mouse(40ug)

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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