Product Name :
HoxA11/D11 (Y248) polyclonal antibody Background :
The homeobox gene HOXA11, also designated homeobox 1I (HOX1I), belongs to the AbdB homeobox family. HoxA11 is necessary for fertility in females as it is a regulator of the cyclic development of the adult endometrium and embryonic uterine development. The expression of HoxA11 increases drastically during the midluteal stage of the menstrual cycle, which is necessary for implantation of the blastocyst. HoxD11 (homeobox D11), also known as HOX4 or HOX4F, is a 338 amino acid protein that contains one homeobox DNA-binding domain and is a member of the Abd-B homeobox family. Localized to the nucleus, HoxD11 functions as a sequencespecific transcription factor that, in conjunction with a variety of other proteins, provides cells with positional identities on their anterior-posterior axis. Defects in the gene encoding HoxD11 are associated with severe limb and genital abnormalities, suggesting that HoxD11 plays an important role in forelimb morphogenesis. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
HoxA11/D11 (Y248) polyclonal antibody detects endogenous levels of HoxA11 and HoxD11 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 200-250 of Human Hox-A11. Conjugate :
Unconjugated Modification :
Unmodification

• 
• 
  Immunohistochemistry (IHC) analyzes of HoxA11/D11 (Y248) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

---

Price/Size :

USD 368/1mg/vial

---

---

Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

---

Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

---

Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

---

Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

---

Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

---