Snail1 (A242) polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
Snail1 (A242) polyclonal antibody Background :
The Snail family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. The Snail-related gene from murine skeletal muscle cells, Smuc, is highly expressed in skeletal muscle and thymus and can, likewise, repress gene transcription. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Snail1 (A242) polyclonal antibody detects endogenous levels of Snail1 protein. Immunogen :
Synthetic phosphopeptide derived from human Snail1 around the phosphorylation site of Serine 246. Conjugate :
Unconjugated Modification :
Unmodification
Snail1 (A242) polyclonal antibody Background :
The Snail family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. The Snail-related gene from murine skeletal muscle cells, Smuc, is highly expressed in skeletal muscle and thymus and can, likewise, repress gene transcription. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Snail1 (A242) polyclonal antibody detects endogenous levels of Snail1 protein. Immunogen :
Synthetic phosphopeptide derived from human Snail1 around the phosphorylation site of Serine 246. Conjugate :
Unconjugated Modification :
Unmodification
-
Western blot (WB) analysis of Snail1 (A242) polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:NIH-3T3 cell lysate Lane3:Rat heart tissue lysate -
Immunohistochemistry (IHC) analyzes of Snail1 (A242) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
A conducive bioceramic/polymer composite biomaterial for diabetic wound healing
PMCID: Pubmed No.:28713016
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial–mesenchymal transition and stemness
PMCID: Pubmed No.:29199005
PDK1 Regulates Vascular Remodeling and Promotes Epithelial-Mesenchymal Transition in Cardiac Development
PMCID: Pubmed No.:20457809
Protein kinase CK2a is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes
PMCID: Pubmed No.:21702981
Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells
PMCID: Pubmed No.:22465710
Downregulation of integrin-linked kinase inhibits epithelial-to-mesenchymal transition and metastasis in bladder cancer cells
PMCID: Pubmed No.:22570869
EGFR inhibition prevents in vitro tumor growth of salivary adenoid cystic carcinoma
PMCID: Pubmed No.:23496982
A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells
PMCID: Pubmed No.:23703635
Expression of TGF-β1, SNAI1 and MMP-9 is associated with lymph node metastasis in papillary thyroid carcinoma
PMCID: Pubmed No.:24276590
Overexpression of HIF-1α, metallothionein and SLUG is associated with high TNM stage and lymph node metastasis in papillary thyroid carcinoma
PMCID: Pubmed No.:24427353
TGFbetaR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness
PMCID: Pubmed No.:24606633
Oroxylin A inhibits hypoxia-induced invasion and migration of MCF-7 cells by suppressing the Notch pathway
PMCID: Pubmed No.:24637576
Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial-mesenchymal transition and ILK signaling pathway
PMCID: Pubmed No.:24768914
Egr-1 Mediates Chronic Hypoxia-Induced Renal Interstitial Fibrosis via the PKC/ERK Pathway
PMCID: Pubmed No.:24819335
Snail regulates the motility of oral cancer cells via RhoA/Cdc42/p-ERM pathway.
PMCID: Pubmed No.:25172658
Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway
PMCID: Pubmed No.:25405790
Oroxylin A inhibits invasion and migration through suppressing ERK/GSK‐3β signaling in snail‐expressing non‐small‐cell lung cancer cells
PMCID: Pubmed No.:26741501
Snail regulates the motility of oral cancer cells via RhoA/Cdc42/p-ERM pathway.
PMCID: Pubmed No.:25172658
Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway
PMCID: Pubmed No.:25405790
Expression of TGF-β1, SNAI1 and MMP-9 is associated with lymph node metastasis in papillary thyroid carcinoma
PMCID: Pubmed No.:24276590
Oroxylin A inhibits invasion and migration through suppressing ERK/GSK‐3β signaling in snail‐expressing non‐small‐cell lung cancer cells
PMCID: Pubmed No.:26741501
Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial-mesenchymal transition and ILK signaling pathway
PMCID: Pubmed No.:24768914
Egr-1 Mediates Chronic Hypoxia-Induced Renal Interstitial Fibrosis via the PKC/ERK Pathway
PMCID: Pubmed No.:24819335
Overexpression of HIF-1α, metallothionein and SLUG is associated with high TNM stage and lymph node metastasis in papillary thyroid carcinoma
PMCID: Pubmed No.:24427353
TGFbetaR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness
PMCID: Pubmed No.:24606633
Oroxylin A inhibits hypoxia-induced invasion and migration of MCF-7 cells by suppressing the Notch pathway
PMCID: Pubmed No.:24637576
lncRNA H19 regulates epithelial–mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA
PMCID: Pubmed No.:28779971
Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway
PMCID: Pubmed No.:25405790
Urocortin Attenuates TGFβ1‐Induced Snail1 and Slug Expressions: Inhibitory Role of Smad7 in Smad2/3 Signaling in Breast Cancer Cells
PMCID: Pubmed No.:26138318
Inhibitor of β-catenin and TCF (ICAT) promotes cervical cancer growth and metastasis by disrupting E-cadherin/β-catenin complex
PMCID: Pubmed No.:29048651
Endothelial‑to‑mesenchymal transition in human idiopathic dilated cardiomyopathy
PMCID: Pubmed No.:29115553
Gambogic acid suppresses cancer invasion and migration by inhibiting TGFβ1-induced epithelial-to-mesenchymal transition
PMCID: Pubmed No.:28404892
TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype
PMCID: Pubmed No.:27418133
Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4
PMCID: Pubmed No.:26636541
RNA m 6 A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail
PMCID: Pubmed No.:31061416
A Soft Microenvironment Protects from Failure of Midbody Abscission and Multinucleation Downstream of the EMT-Promoting Transcription Factor Snail
PMCID: Pubmed No.:29483094
α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells
PMCID: Pubmed No.:29477470
The AKT/GSK3β-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1
PMCID: Pubmed No.:32331534
Radiofrequency ablation triggers the migration of hepatocellular carcinoma cells by suppressing miR-148a-5p
PMCID: Pubmed No.:32142478
Absent in melanoma 2 suppresses epithelial‐mesenchymal transition via Akt and inflammasome pathways in human colorectal cancer cells
PMCID: Pubmed No.:31210372
Promotion effects of mono‐2‐ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF‐β signals
PMCID: Pubmed No.:31667872
MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance
PMCID: Pubmed No.:36929633
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.