IGF-1R (G1155) polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
IGF-1R (G1155) polyclonal antibody Background :
Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
IGF-1R (G1155) polyclonal antibody detects endogenous levels of IGF-1R protein. This antibody may cross-reacts with insulin receptor protein. Immunogen :
Synthetic peptide, corresponding to amino acids 1121-1170 of Human IGF-1R. Conjugate :
Unconjugated Modification :
Unmodification
IGF-1R (G1155) polyclonal antibody Background :
Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
IGF-1R (G1155) polyclonal antibody detects endogenous levels of IGF-1R protein. This antibody may cross-reacts with insulin receptor protein. Immunogen :
Synthetic peptide, corresponding to amino acids 1121-1170 of Human IGF-1R. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of IGF-1R (G1155) pAb at 1:500 dilution Lane1:AML-12 whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:HepG2 whole cell lysate(40ug) Lane4:Panc1 whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(40ug) -
Immunohistochemistry (IHC) analyzes of IGF-1R (G1155)_x000D_ antibody in paraffin-embedded human breast carcinoma tissue.
Osteogenic potential of bone marrow stromal cells derived from streptozotocin-induced diabetic rats.
PMCID: Pubmed No.:23292283
Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells
PMCID: Pubmed No.:None
Decoy Oligonucleotide Rescues IGF1R Expression from MicroRNA-223 Suppression
PMCID: Pubmed No.:24324762
A Post-Transcriptional Regulation of Tumor Suppressor MiR-139-5p and A Network of MiR-139-5p Mediated mRNAs Interactions in Colorectal Cancer.
PMCID: Pubmed No.:24942287
MiR-100 Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion and Enhances Chemosensitivity by Targeting IGFIR
PMCID: Pubmed No.:26306402
Decoy Oligonucleotide Rescues IGF1R Expression from MicroRNA-223 Suppression
PMCID: Pubmed No.:24324762
Effects of Curcumin on Epidermal Growth Factor in Proliferative Vitreoretinopathy
PMCID: Pubmed No.:29975931
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.