Caveolin-1 (V163) polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
Caveolin-1 (V163) polyclonal antibody Background :
Caveolae (also known as plasmalemmal vesicles) are 50-100 nM flask-shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL) across capillary endothelial cells, uptake of small molecules via potocytosis, and the compartmentalization of certain signaling molecules, including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3, have been identified as principal components of caveolae. Two forms of caveolin-1, designated α and β, share a distinct but overlapping cellular distribution and differ by an amino-terminal 31 amino acid sequence which is absent from the β isoform. Caveolin-1 shares 31% identity with caveolin-2 and 65% identity with caveolin-3 at the amino acid level. Functionally, the three proteins differ in their interactions with heterotrimeric G protein isoforms. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Caveolin-1 (V163) polyclonal antibody detects endogenous levels of Caveolin-1 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 150-200 of Human Caveolin-1. Conjugate :
Unconjugated Modification :
Unmodification
Caveolin-1 (V163) polyclonal antibody Background :
Caveolae (also known as plasmalemmal vesicles) are 50-100 nM flask-shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL) across capillary endothelial cells, uptake of small molecules via potocytosis, and the compartmentalization of certain signaling molecules, including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3, have been identified as principal components of caveolae. Two forms of caveolin-1, designated α and β, share a distinct but overlapping cellular distribution and differ by an amino-terminal 31 amino acid sequence which is absent from the β isoform. Caveolin-1 shares 31% identity with caveolin-2 and 65% identity with caveolin-3 at the amino acid level. Functionally, the three proteins differ in their interactions with heterotrimeric G protein isoforms. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Caveolin-1 (V163) polyclonal antibody detects endogenous levels of Caveolin-1 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 150-200 of Human Caveolin-1. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of Caveolin-1 (V163) polyclonal antibody at 1:500 dilution Lane1:A549 cell lysate Lane2:Mouse kidney tissue lysate Lane3:Rat kidney tissue lysate
Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin
PMCID: Pubmed No.:23246481
Profiling metabolic remodeling in PP2A cα deficiency and chronic pressure overload mouse hearts
PMCID: Pubmed No.:26497085
Profiling metabolic remodeling in PP2A cα deficiency and chronic pressure overload mouse hearts
PMCID: Pubmed No.:26497085
Profiling metabolic remodeling in PP2Acα deficiency and chronic pressure overload mouse hearts
PMCID: Pubmed No.:26497085
Sulfatide interacts with and activates integrin αVβ3 in human hepatocellular carcinoma cells
PMCID: Pubmed No.:27145276
miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4
PMCID: Pubmed No.:29484417
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.