PENK polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
PENK polyclonal antibody Background :
The Proenkephalin precursor proteins are secreted proteins belonging to the opioid neuropeptide precursor family. The proenkephalin proteins are proteolytically processed to form active secreted opioid peptides which function as ligands for the κ-type of opiod receptor. Proenkephalin A precursor contains Synenkephalin, Leu-enkephalin and Met-enkephalin processed active peptides while the Proenkephalin B precursor contains β-neoendorphin, Dynorphin, Leumorphin, Leu-enkephalin and Rimorphin processed active peptides. β-endorphin and Met-enkephalin are endogenous opiates while ACTH is crucial for adrenal gland stimulation to release cortisol. MSH increases Melanin production in melanocytes which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP-K and PI 3-K pathways. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
PENK polyclonal antibody detects endogenous levels of PENK protein. Immunogen :
Recombinant full length Human PENK. Conjugate :
Unconjugated Modification :
Unmodification
PENK polyclonal antibody Background :
The Proenkephalin precursor proteins are secreted proteins belonging to the opioid neuropeptide precursor family. The proenkephalin proteins are proteolytically processed to form active secreted opioid peptides which function as ligands for the κ-type of opiod receptor. Proenkephalin A precursor contains Synenkephalin, Leu-enkephalin and Met-enkephalin processed active peptides while the Proenkephalin B precursor contains β-neoendorphin, Dynorphin, Leumorphin, Leu-enkephalin and Rimorphin processed active peptides. β-endorphin and Met-enkephalin are endogenous opiates while ACTH is crucial for adrenal gland stimulation to release cortisol. MSH increases Melanin production in melanocytes which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP-K and PI 3-K pathways. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
PENK polyclonal antibody detects endogenous levels of PENK protein. Immunogen :
Recombinant full length Human PENK. Conjugate :
Unconjugated Modification :
Unmodification
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WesternBlot (WB) analysis of PENK polyclonal antibody
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.