CBX8 polyclonal antibody 
Datasheet
COA
MSDS
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Product Name :
CBX8 polyclonal antibody Background :
Polycomb group (PcG) proteins form multiprotein complexes and play a role in gene silencing and Hox gene regulation by altering chromatin structure during transcription. The PcG protein MPc3 is also known as CBX8, PC3, HPc3 or RC1. MPc2 and MPc3 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1. However, MPc3 has only been shown to bind RING1 in vivo with covalently modified forms of RING1. MPc3 also interacts with the carboxy-terminus of AF9, a transcriptional activator implicated in the development of acute lukemias. MPc3 acts as a long range transcriptional silencer when targeted to a reporter gene by a heterologous DNA-binding domain. The human MPc3 gene maps to chromosome 17q25.3 and encodes a 389 amino acid protein. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
CBX8 polyclonal antibody detects endogenous levels of CBX8 protein. Immunogen :
Recombinant full length Human CBX8. Conjugate :
Unconjugated Modification :
Unmodification
CBX8 polyclonal antibody Background :
Polycomb group (PcG) proteins form multiprotein complexes and play a role in gene silencing and Hox gene regulation by altering chromatin structure during transcription. The PcG protein MPc3 is also known as CBX8, PC3, HPc3 or RC1. MPc2 and MPc3 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1. However, MPc3 has only been shown to bind RING1 in vivo with covalently modified forms of RING1. MPc3 also interacts with the carboxy-terminus of AF9, a transcriptional activator implicated in the development of acute lukemias. MPc3 acts as a long range transcriptional silencer when targeted to a reporter gene by a heterologous DNA-binding domain. The human MPc3 gene maps to chromosome 17q25.3 and encodes a 389 amino acid protein. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
CBX8 polyclonal antibody detects endogenous levels of CBX8 protein. Immunogen :
Recombinant full length Human CBX8. Conjugate :
Unconjugated Modification :
Unmodification
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WesternBlot (WB) analysis of CBX8 polyclonal antibod
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.