OAS1 polyclonal antibody 
Datasheet
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MSDS
SHIP
Product Name :
OAS1 polyclonal antibody Background :
The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
OAS1 polyclonal antibody detects endogenous levels of OAS1 protein. Immunogen :
Recombinant full length Human OAS1. Conjugate :
Unconjugated Modification :
Unmodification
OAS1 polyclonal antibody Background :
The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
OAS1 polyclonal antibody detects endogenous levels of OAS1 protein. Immunogen :
Recombinant full length Human OAS1. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot analysis of extracts of mouse liver cells, using OAS1 antibody.
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.