Product Name :
MUC6 polyclonal antibody Background :
Mucin 6 (also designated MUC 6 and gastricmucin) is a large glycoprotein that plays amajor role in the protection of the gastrointestinal tract. MUC6 carries GlcNAcα1→4Galβ→R structures, indicating thatα1, 4-N-acetylglucosaminyltransferase isimportant to the formation of the mucous glycoproteinsin vivo. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileumand rightcolon. In gastriccancer, Mucin 6 has an altered expression. In normalstomach, Mucin 6 apomucin is associated with Lewistype 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deepermucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation. Mucin 6mRNA is expressed transientlyin the nephrogeniczone of the kidneyin the early mid-trimester of development, and Mucin 6 glycoprotein is expressed in the epithelium of ureteric buds and collecting ducts, but absent fromadultkidney. Proliferating bile ductularcells express Mucin 6 apomucin in diseased liver, especially in chronicviral hepatitiswith active necroinflammation,suggesting that this secreted mucin acts as a cytoprotective agent and represents a phenotype of reactive biliary epithelium in chronicviral hepatitis. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
MUC6 polyclonal antibody detects endogenous levels of MUC6 protein. Immunogen :
A synthetic peptide corresponding to residues in Human MUC6. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of MUC6 pAb at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:Aml-12 whole cell lysate(40ug) Lane3:Hela whole cell lysate(40ug) Lane4:A2780 whole cell lysate(40ug) Lane5:The Fallopian tube tissue lysate of Mouse(40ug) Lane6:HepG2 whole cell lysate (40ug)

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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