Product Name :
Thyroglobulin monoclonal antibody Background :
Thyroglobulin is a large preprotein containing multiple glycosylation sites. Located in the thyroid gland, Thyroglobulin is the precursor of the iodinated thyroid hormones Thyroxine and Triiodothyronine. Thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulum, prior to forming dimers. This dimerization, as well as export of Thyroglobulin to the Golgi complex, has been shown to require Ca2+. Defects in Thyroglobulin are known to cause some types of goiter (an enlargement of the thyroid gland). This condition is thought to result from defective dimerization and transport of Thyroglobulin to the Golgi complex. Product :
Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of Thyroglobulin protein. Immunogen :
KLH-conjugated synthetic peptide encompassing a sequence within human Thyroglobulin. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification

• 
• 
  Immunohistochemical analysis of Thyroglobulin staining in human follicular thyroid carcinoma formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

---

Price/Size :

USD 368/1mg/vial

---

---

Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

---

Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

---

Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

---

Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

---

Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

---