CCAR1 polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
CCAR1 polyclonal antibody Background :
CARP-1 (cell division cycle and apoptosis regulator 1), also known as CCAR1 or DIS, is a 1,150 amino acid protein that localizes to the perinuclear region of the cytoplasm and contains one SAP domain. Expressed in several epithelial cancer cell lines, including breast, colon, prostate and leukemia, CARP-1 is involved in apoptotic signaling, as well as in cell cycle progression and cell proliferation via interaction with c-Myc and cyclin B1. CARP-1 is subject to DNA damage-induced phosphorylation, probably by ATM or ATR. The gene encoding CARP-1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. Product :
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
CCAR1 polyclonal antibody detects endogenous levels of CCAR1 protein. Immunogen :
KLH conjugated synthetic peptide derived from human DIS/CCAR1: 731-830/1150 Conjugate :
Unconjugated Modification :
Unmodification
CCAR1 polyclonal antibody Background :
CARP-1 (cell division cycle and apoptosis regulator 1), also known as CCAR1 or DIS, is a 1,150 amino acid protein that localizes to the perinuclear region of the cytoplasm and contains one SAP domain. Expressed in several epithelial cancer cell lines, including breast, colon, prostate and leukemia, CARP-1 is involved in apoptotic signaling, as well as in cell cycle progression and cell proliferation via interaction with c-Myc and cyclin B1. CARP-1 is subject to DNA damage-induced phosphorylation, probably by ATM or ATR. The gene encoding CARP-1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. Product :
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
CCAR1 polyclonal antibody detects endogenous levels of CCAR1 protein. Immunogen :
KLH conjugated synthetic peptide derived from human DIS/CCAR1: 731-830/1150 Conjugate :
Unconjugated Modification :
Unmodification
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.