NR2C2 monoclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
NR2C2 monoclonal antibody Background :
Testicular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2 . TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs) . TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation . TR4 can interact with other hormone receptors such as AR and ER to influence protein-protein binding and target gene inactivation . High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2 . Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis . Product :
Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of NR2C2 protein. Immunogen :
KLH-conjugated synthetic peptide of human NR2C2. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification
NR2C2 monoclonal antibody Background :
Testicular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2 . TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs) . TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation . TR4 can interact with other hormone receptors such as AR and ER to influence protein-protein binding and target gene inactivation . High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2 . Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis . Product :
Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of NR2C2 protein. Immunogen :
KLH-conjugated synthetic peptide of human NR2C2. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot analysis of NR2C2 expression in PC3 (A), Jurkat (B), MoLT4 (C), F9 (D), NIH3T3 (E), PC12 (F), CHO (G) whole cell lysates.
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.