Product Name :
Gamma-catenin monoclonal antibody Background :
Also known as plakoglobin, 纬-catenin is a member of the Armadillo family of signaling molecules, which includes 尾-catenin and the聽Drosophila聽protein armadillo . This family of proteins is involved in Wnt signaling, which is important in embryonic development and in tumorigenesis . Although the two vertebrate proteins 尾- and 纬-catenin display sequence homology, 纬-catenin likely plays a role distinct from that of 尾-catenin . 纬-catenin localizes to desmosomes and adherens junctions, both sites of intercellular adhesion, and interacts with the cytoplasmic domains of classical and desmosomal cadherins. Interaction of 纬- or 尾-catenin with 伪-catenin, desmoplakin and other junction proteins provides a link between intercellular junctions and the actin and intermediate filament cytoskeleton. Maintenance and/or modification of this link is vital for control of cell adhesion and migration . 纬-catenin is modified by phosphorylation, affecting both adhesion and 尾-catenin dependent transcription , and by and O-glycosylation, affecting adhesion . Recent evidence suggests that 纬-catenin regulates desmosomal adhesion in response to growth factor stimulation . Product :
Mouse IgG3. Supplied in crude ascites with 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of Gamma-catenin protein. Immunogen :
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Gamma-catenin. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification

• 
  Western blot analysis of Gamma-catenin expression in NCIH292 (A) whole cell lysates.

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

---

Price/Size :

USD 368/1mg/vial

---

---

Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

---

Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

---

Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

---

Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

---

Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

---