Cytochrome P450 1A2 monoclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
Cytochrome P450 1A2 monoclonal antibody Background :
CYP1A2, also called cytochrome P450 1A2, is a heme-thiolate monooxygenase enzyme involved in the NADPH-dependent electron transport pathway of liver microsomes. A member of the cytochrome P450 family, CYP1A2 oxidizes fatty acids, steroids and xenobiotics. It is also involved in the metabolism of imiprimine, propranol and clozapine. CYP1A2 localizes to the membrane of the endoplasmic reticulum. It is induced by 3-methylcholanthrene, Insulin, modafinil and hyperforin and inhibited by many fluoroquinolone antibiotics, caffeine, fluvoxamine and cimetidine. In addition, the involvement of CYP1A2 in the metabolism of estrogen is associated with a reduced risk of breast cancer. Product :
Mouse IgG3. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of Cytochrome P450 1A2 protein. Immunogen :
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cytochrome P450 1A2. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification
Cytochrome P450 1A2 monoclonal antibody Background :
CYP1A2, also called cytochrome P450 1A2, is a heme-thiolate monooxygenase enzyme involved in the NADPH-dependent electron transport pathway of liver microsomes. A member of the cytochrome P450 family, CYP1A2 oxidizes fatty acids, steroids and xenobiotics. It is also involved in the metabolism of imiprimine, propranol and clozapine. CYP1A2 localizes to the membrane of the endoplasmic reticulum. It is induced by 3-methylcholanthrene, Insulin, modafinil and hyperforin and inhibited by many fluoroquinolone antibiotics, caffeine, fluvoxamine and cimetidine. In addition, the involvement of CYP1A2 in the metabolism of estrogen is associated with a reduced risk of breast cancer. Product :
Mouse IgG3. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of Cytochrome P450 1A2 protein. Immunogen :
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cytochrome P450 1A2. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification
-
Western blot analysis of Cytochrome P450 1A2 expression in SKBR3 (A) whole cell lysates.
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.