PENK monoclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
PENK monoclonal antibody Background :
The corticotropin-lipotropin protein, also designated pro-opiomelanocortin,belongs to the POMC family of proteins. Specific cleavages by enzymes at certain basic paired residues yield various processed active peptides. The corticotropin-lipotropin protein contains synenkephalin, Leu-enkephalin, NPP, a-, b- and g-melanotropin (MSH), adrenocorticotropic hormone (ACTH), lipotropin b and g, b-endorphin and Met-enkephalin processed active peptides.b-endorphin and Met-enkephalin are endogenous opiates while ACTH is crucial for adrenal gland stimulation to release cortisol. Met/Leu-enkephalins also function in pain perception and response to stress. MSH increased melanin production in melanocytes which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP-K and PI3-K pathways. Product :
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of PENK protein. Immunogen :
Recombinant fusion protein of human PENK. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification
PENK monoclonal antibody Background :
The corticotropin-lipotropin protein, also designated pro-opiomelanocortin,belongs to the POMC family of proteins. Specific cleavages by enzymes at certain basic paired residues yield various processed active peptides. The corticotropin-lipotropin protein contains synenkephalin, Leu-enkephalin, NPP, a-, b- and g-melanotropin (MSH), adrenocorticotropic hormone (ACTH), lipotropin b and g, b-endorphin and Met-enkephalin processed active peptides.b-endorphin and Met-enkephalin are endogenous opiates while ACTH is crucial for adrenal gland stimulation to release cortisol. Met/Leu-enkephalins also function in pain perception and response to stress. MSH increased melanin production in melanocytes which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP-K and PI3-K pathways. Product :
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of PENK protein. Immunogen :
Recombinant fusion protein of human PENK. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot analysis of PENK expression in T47D (A) whole cell lysates.
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.