MAFK monoclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
MAFK monoclonal antibody Background :
Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter.c-Maf (Maf-2) and the closely related family members Neural retina leucine zipper (Nrl), L-Maf and Krml1/MafB (Maf-1) all bind to T-MARE sites and are implicated in a wide variety of developmental and physiologic roles. The three small Maf family proteins MafF, MafG and MafK are components of NF-E2 which function as heterodimers with the large tissue restricted subunit of NF-E2 called p45, and furthermore are implicated in the transcriptional regulation of many erythroid-specific genes. MafG is ubiquitously expressed, with highest expression in the VMS, heart and skeletal muscle; its expression is induced in response to stress. MafK, also designated NF-E2 p18, is primarily expressed during development in mesenchymal and hematopoietic cells and neurons. MafK heterodimerizes with NF-E2 and various CNC proteins. MafF is most abundantly expressed in the lung and is thought to compensate for loss of function mutations in MafG and MafK. Product :
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of MAFK protein. Immunogen :
KLH-conjugated synthetic peptide of human MAFK. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification
MAFK monoclonal antibody Background :
Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter.c-Maf (Maf-2) and the closely related family members Neural retina leucine zipper (Nrl), L-Maf and Krml1/MafB (Maf-1) all bind to T-MARE sites and are implicated in a wide variety of developmental and physiologic roles. The three small Maf family proteins MafF, MafG and MafK are components of NF-E2 which function as heterodimers with the large tissue restricted subunit of NF-E2 called p45, and furthermore are implicated in the transcriptional regulation of many erythroid-specific genes. MafG is ubiquitously expressed, with highest expression in the VMS, heart and skeletal muscle; its expression is induced in response to stress. MafK, also designated NF-E2 p18, is primarily expressed during development in mesenchymal and hematopoietic cells and neurons. MafK heterodimerizes with NF-E2 and various CNC proteins. MafF is most abundantly expressed in the lung and is thought to compensate for loss of function mutations in MafG and MafK. Product :
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of MAFK protein. Immunogen :
KLH-conjugated synthetic peptide of human MAFK. The exact sequence is proprietary. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot analysis of MAFK expression in Jurkat (A) whole cell lysates.
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.