Product Name :
CALU monoclonal antibody Background :
Calumenin belongs to the CREC family of proteins that also contains reticulocalbin, ERC-55/TCBP-49/E6BP, Cab45, and crocalbin/CBP-50. These EF-hand proteins localize to the endoplasmic reticulum (ER) and are involved in the secretory pathway in mammalian cells. Calumenin exists as two isoforms corresponding to alternativly spliced variants of the CALU gene. Calumenin has been shown to localize to the ER via a carboxy terminal HDEF ER retention signal, and undergoes secretion after trafficking through the secretory pathway. Secreted calumenin plays a role in amyloidosis by interacting with serum amyloid P component. Calumenin is also a chaperone for mutants of the cystic fibrosis transmembrane conductance regulator (CFTR). Researchers performing a proteomics analysis of endometrial cancer identified calumenin as a potential target for endometrial carcinoma. Product :
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of CALU protein. Immunogen :
Purified recombinant human Calumenin protein fragments expressed in E.coli. Conjugate :
Unconjugated Modification :
Unmodification

• 
  Western blot analysis of CALU expression in SW480 (A), mouse intestine (B), A431 (C) whole cell lysates.

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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