Product Name :
NAT10 Rabbit monoclonal antibody Background :
N-acetyltransferase 10 (NAT10), also known as human N-acetyltransferase-like protein (hALP), is an acetyltransferase which increases telomerase activity through the activation of the TERT promoter. NAT10 localizes to the midbody in late phase mitosis to help achieve cytokinesis. It has been found that DNA damage can actually increase NAT10-dependent acetylation of alpha-tubulin, resulting in increased stability of the protein. This increased stability of microtubules has been linked to the sequestration of the nuclear import factor Transportin-1 in the premature aging disease, progeria. NAT10 can also function as an acetyltransferase for both rRNA and mRNA. The acetylation of the 18 S rRNA helps in rRNA processing and ribosome biogenesis, and this process can be disrupted by opposing activity of the deacetylase SirT1 in response to stress. mRNA acetylation by NAT10 plays a role in translation efficiency and mRNA stability. NAT10 is overexpressed in many different cancer types, making it a good potential therapeutic target. Product :
Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Recognizes endogenous levels of NAT10 protein. Immunogen :
Recombinant protein of human NAT10 Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot analysis of NAT10 expression in Jurkat (A), C6 (B), Hela (C) whole cell lysates.
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Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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