Product Name :
ACE2 mutant protein:R393G,human,recombinant(hFc Tag) Background :
Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl. Product :
PBS,pH7.4 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
AA Gln 18 - Ser 740 (Accession # Q9BYF1-1) Immunogen :
pathway :

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  1-293F negative control 2-293F transfection IgG2-ACE2-393G-hFC Supernatant of cell cracking fluid 3-293F transfection IgG2-ACE2-393G-hFC Cell supernatant

Blocking peptide available as NCP0095P