IκB-β (S23) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
IκB-β (S23) Peptide Applications :
Blocking Background :
The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins .Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB . IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified.The regulation of IκBβ and IκBε is similar to that of IκBα. However, the phosphorylation and ubiquitin-mediated degradation of these proteins occurs with much slower kinetics. IKK phosphorylation of IκBβ occurs at Ser19 and Ser23, while IκBε can be phosphorylated at Ser18 and Ser22 . Alternative Name :
I kappa B beta; IKB B; IKB beta; IKBB; IkBbeta; IkappaBbeta; NF kappa B inhibitor beta; NF kappa BIB; NFKBIB; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor beta; TR interacting protein 9; TRIP 9; TRIP9; Thyroid receptor Swiss-Prot :
Q15653 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IκB-β (S23). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using AP0636 IκB-β (S23) pAb.
IκB-β (S23) Peptide Applications :
Blocking Background :
The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins .Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB . IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified.The regulation of IκBβ and IκBε is similar to that of IκBα. However, the phosphorylation and ubiquitin-mediated degradation of these proteins occurs with much slower kinetics. IKK phosphorylation of IκBβ occurs at Ser19 and Ser23, while IκBε can be phosphorylated at Ser18 and Ser22 . Alternative Name :
I kappa B beta; IKB B; IKB beta; IKBB; IkBbeta; IkappaBbeta; NF kappa B inhibitor beta; NF kappa BIB; NFKBIB; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor beta; TR interacting protein 9; TRIP 9; TRIP9; Thyroid receptor Swiss-Prot :
Q15653 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IκB-β (S23). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using AP0636 IκB-β (S23) pAb.
Blocking peptide available as AP0636PP