Bioworld Technology, Inc.

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ISG15 polyclonal antibody

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	Catalog No.	Package Size	Price
	BS6220	50ul	enquire
	BS6220	100ul	enquire

	Catalog No.	Package Size	Price
	BS6220	50ul	$208
	BS6220	100ul	$358

Quantity: Total:$358

Bioworld Technology,Inc
1660 South Highway 100, Suite 500
St. Louis Park, MN 55416
Tel: 612-326-3284
Fax: 612-293-3841
Email: info@bioworlde.com
Support email: support@bioworlde.com

Catalog No.	BS6220
Product Name	ISG15 polyclonal antibody
Applications	WB IHC
Alternative Name	Ubiquitin-like protein ISG15; Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; IP17; Ubiquitin cross-reactive protein; hUCRP; ISG15; G1P2; UCRP
Swiss-Prot	P05161
Host	Rabbit
Reactivity	Human,Mouse,Rat
Application_all	WB: 1:500~1:2000 IHC: 1:50~1:200
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity	ISG15 polyclonal antibody detects endogenous levels of ISG15 protein.
BiowMW	~ 18 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Recombinant full length Human ISG15.

WesternBlot (WB) analysis of ISG15 polyclonal antibody in extracts from Human brain tissue, hela cells and mouse kidney tissue.

Background

Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.

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For Research Use Only. Not For Use In Diagnostic Procedures.

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