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Product Catalog
p-NF2 (S518) Antibody
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Catalogue No : BS4800
| Host | Reactivity | Size | Application | stock | price | cart |
| BS4800 | H,M,R | 100μg | WB IF |  |
258.00 |  |
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Contact information
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Product
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Purification & Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Specificity
p-NF2 (S518) antibody detects endogenous levels of p-NF2 protein.
Applications (Recommended Dilutions)
WB: 1:500~1:1000 IF:1:50~1:200
Western Blot(WB)
Western blot (WB) analyzes of p-NF2 (S518) antibody in extracts from Jurkat IFN cells.
Storage&Stability
Store at 4
Background
Neurofibromatosis type 2 (NF2) is a dominantly inherited disorder characterized by the occurance of bilateral vestibular schwannomas and other central nervous system tumors, including multiple meningiomas. NF2 occurs in about 1 of 40,000 live births. The NF2 gene is highly penetrant; NF2-affected individuals have a 95% chance of developing bilateral vestibular schwannomas. NF2 is distinct from NF1, which is characterized by an incidence of 1 in 4000, maps to chromosome 17 and encodes a protein designated neurofibromin, which is a large protein with a GAP domain. Genetic linkage studies of both sporadic and familial tumors suggest that NF2 is caused by inactivation of a tumor suppressor gene that maps on chromosome 22q12 and encodes a 595 amino acid protein whose function appears to be mediated by interaction with the cytoskeleton.