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Product Catalog
Tau (P206) Antibody
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Catalogue No : BS3639
| Host | Reactivity | Size | Application | stock | price | cart |
| BS3639 | H,M,R | 100μg | WB IF |  |
258.00 |  |
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Contact information
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Product
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Purification & Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Specificity
Tau (P206) antibody detects endogenous levels of Tau protein.
Applications (Recommended Dilutions)
WB: 1:500~1:1000 IF:1:50~1:200
Western Blot(WB)
Western blot (WB) analyzes of Tau (P206) antibody in extracts from mouse brain cells.
Storage&Stability
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Background
Tau can be phosphorylated by several protein kinases. Phosphorylation by Tau protein kinase II at Serine 404 is primarily responsible for the functional loss of Tau-mediated tubulin polymerization. In addition, phosphorylation of microtubule- associated Tau results in the dissociation of Tau from the microtubules and tubulin depolymerization. Serine 412 of Tau is modified by Tau protein kinase I/glycogen synthase kinase-3β (TPKI/GSK-3β) to disrupt neuronal metabolism in anatomical areas vulnerable to Alzheimer’s disease. TPKI/ GSK-3β is expressed primarily in neurons and especially in neurites early in development, whereafter the distribution is concentrated mostly in the cell soma and the proximal neurite region.