Email:shdiahds@163.com
Phone:+1-909-839-7620
Fax:+1-909-839-7620
Click here for qusetions for this product!
Product Catalog
HDAC6 (Q18) pAb
| Host | Reactivity | Size | Application | stock | price | cart |
| Rabbit | H,M, | 100μg | IHC IF |  |
258.00 |  |
|
Contact information
|
||||||
Product
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Molecular Weight
~ 131 kDa
Purification & Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Specificity
HDAC6 (Q18) pAb detects endogenous levels of HDAC6 protein.
Applications (Recommended Dilutions)
IHC: 1:50~1:200 IF:1:50~1:200
Western Blot(WB)
Western blot (WB) analysis of HDAC6 (Q18) pAb in extracts from HepG2 cells.
Immunohistochemistry (IHC)
Immunohistochemistry (IHC) analyzes of HDAC6 (Q18) pAb in paraffin-embedded human testis tissue.
Storage&Stability
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Background
HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.