Email:shdiahds@163.com
Phone:+1-909-839-7620
Fax:+1-909-839-7620
Click here for qusetions for this product!
Product Catalog
E-Cadherin1/2/3/4 (R868) Antibody
Current Country :
Download PDF Datasheet
Catalogue No : BS1098
| Host | Reactivity | Size | Application | stock | price | cart |
| BS1098 | H,M,R | 100μg | WB IHC IF |  |
218.00 |  |
|
Contact information
|
||||||
Product
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Purification & Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Specificity
E- Cadherin1/2/3/4(R868) antibody detects endogenous levels of E-Cadherin1/2/3/4 protein.
Applications (Recommended Dilutions)
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:100~1:500
Western Blot(WB)
Western blot (WB) analysis of Cadherin1/2/3/4 (R868) antibody in extracts from NIH/3T3 cells.
Immunohistochemistry (IHC)
Immunohistochemistry (IHC) analyzes of Cadherin1/2/3/4 (R868) antibody in paraffin-embedded human breast carcinoma tissue.
Storage&Stability
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Background
Cadherins are members of a multigene family of single chain glycoprotein receptors mediating calcium dependent cell-cell adhesion. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherins are expressed in a tissue specific manner and and are required for assembly of cells into solid tissue. Individual cadherin molecules are known to co-operate with each other to form a linear cell adhesion zipper. In adhesion junctions cadherins are bound to beta and gamma catenins which in turn bind to alpha catenin, an actin binding protein. Cadherins play an important part in tumor invasion and metastasis.