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Product Catalog
AR (E646) pAb
| Host | Reactivity | Size | Application | stock | price | cart |
| Rabbit | H | 100μg | WB IHC |  |
258.00 |  |
|
Contact information
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Product
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Molecular Weight
~ 110 kDa
Purification & Purity
The pAb was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Specificity
Androgen Receptor(E646) pAb detects endogenous levels of Androgen Receptor.
Applications (Recommended Dilutions)
WB: 1:500~1:1000 IHC: 1:50~1:200
Immunohistochemistry (IHC)
Immunohistochemistry (IHC) analysis of Androgen Receptor (E646) pAb in paraffin-embedded human prostate carcinoma tissue.
Storage&Stability
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Background
Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and make reproductive physiology. The androgen receptor (AR) is a member of the steroid superfamily of liganddependent transcription factors. ARs bind the two biologically active androgens, testosterone (T) and dihydrotestosterone (DHT), with high and nearly identical affinities; however, the rates of association and dissociation of T are about three times more rapid than those of DHT. This difference has resulted in speculation as to whether these differences in binding kinetics could account for the different physiological effects of T and DHT. A striking feature of AR is its rapid degradation in the absence of ligand. It is now well established that androgen binding results in an at least six-fold increase in androgen stability and that ligand-induced stabilization of AR is highly androgen- specific.